Macronutrients, especially protein and energy, are important in pressure injury healing. Sufficient energy is necessary to meet increased metabolic demands and prevent the body from breaking down protein for energy instead of using it for tissue repair. Fortisip Compact Protein provides 300 kcal and 18 g of protein in a compact 125 ml or half-cup user-friendly bottle and is available in six flavour variants. Its small half-cup size and flavour options appeal to individuals with poor appetite and taste changes. Cubitan provides 249 kcal and 18 g of protein in a 200 ml vanilla flavour variant. Each bottle contains 3 g of L-arginine, which plays a supporting role in wound healing and works best as part of a high-protein, energy-rich oral nutritional supplement. Fortisip Compact Protein and Cubitan are high-protein oral nutritional supplements, with more than 20 percent of total energy coming from protein. A recent systematic review and meta-analysis showed that high-protein oral nutritional supplements have a significant clinical impact on adults at risk of malnutrition by reducing infections, reducing pressure injuries, improving wound and fracture healing, and reducing post-operative complications. Fortisip and Cubitan are supported by more than 20 years of research, including over 20 published clinical studies involving more than 2,000 adults at risk of malnutrition.